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CD40 ligand deficiency (hyper-IgM syndrome)
= CD40L
= CD154
a protein that is primarily expressed on activated T cells
binds to CD40 on antigen-presenting cells (APC)
CD40 ligand deficiency
(hyper-IgM syndrome)
Inability of T cells
to activate B cell
Ig class switching
=> only IgM is produced
=> ↓other Ig